Circuit Mechanisms underlying Brain Disorders

We combine brain circuit modeling with neuromodulation, imaging, and behavioral experiments in vivo to discover, test, and validate circuit mechanisms underlying brain disorders. In other words, we study brain disease models to determine which brain circuits go “haywire” and malfunction. This has led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation.¬†Understanding circuit mechanisms that drive behavioral dysfunction is critical for diagnosis and treatment of neurological diseases.

Our lab is interested in understanding how the brain works at the systems level.